Unidad I : Interacción Candida albicans - Hospedador

Interaccion Patogeno - Hospedador
The C. albicans - macrophage model

Candida albicans is a pathogenic opportunistic fungus which can be found as a component of the usual flora in human mucoses. This commensalist balance can be fragile, though. In the case of immunosuppressed patients, Candida cells can overproliferate and become pathogenic. Cells in yeast form may produce hyphae, then penetrate tissues and eventually may cause invasive candiasis. At present, the frequency of this fatal opportunistic mycosis continues to be distressing and, unfortunately, resolution is hindered by the reduced effectiveness and serious side-effects of the few currently available drugs, the appearance of antifungal-drug resistance, and the lack of accurate and prompt diagnostic procedures. To address proteomics studies involving the way Candida interacts with immune cells is thus essential in order to improve our comprehension of the process of infection and represents one primary step of investigation that could lead to the development of diagnosis methods, vaccines and antifungal drugs