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Alveolar Cells and Lung Surfactant

 

Director: Prof. Cristina Casals

 

Our laboratory has studied the pulmonary surfactant system under normal and pathological conditions for more than 20 years. The main lines of research are:

  • Membrane biochemistry and biophysics.

  • Structure-function relationships in surfactant proteins.

  • Role of pulmonary surfactant in lung physiopathology.

These studies employ an array of techniques including biophysical, biochemical, immunological, cellular, and physiological.

 

 

Key words:

 

Membranes, monolayers, SP-A, SP-B, SP-C, collectins, lipid-protein interaction, protein-protein interaction, collagen, bacterial lipopolysaccharide, beta-(1,3) glucan, FK506, KL4, alveolar macrophages, type II cells, innate immune defence, acute lung injury, and lung transplantation.

 

 

Public Funding:

 

MICINN National Program of Research and Development

Ciberes Spanish Research Center of Respiratory Diseases

CAMAutonomous Community of Madrid-Innovation and Research System

 

 

Private Funding:

 

Nycomed GmbH, Germany

Fujisawa GmbH, Gernany

Laboratorios Dr. Esteve, Barcelona

Fundación MM, Madrid

 

 



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